Influence of outer membrane permeabilization on intrinsic resistance to the hydrophobic biocide triclosan in opportunistic Serratia species
Triclosan is a hydrophobic antimicrobial agent commonly employed in health care settings.While it exhibits broad-spectrum antibacterial properties, the gram-negative nosocomial opportunists Pseudomonas aeruginosa and Serratia marcescens are atypically refractory.Intrinsic resistance to triclosan in P.aeruginosa is largely due to its outer membrane